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Incidence of Seizures With Tricyclic and Tetracyclic Antidepressants
Bahman Jabbari, MD;
George E. Bryan, MD;
Ellis E. Marsh, MD;
Carl H. Gunderson, MD
Arch Neurol. 1985;42(5):480-481.
Abstract
• One hundred eighty-six depressed psychiatric inpatients were seen at our institution during 1982. Forty-five of these patients were treated with tricyclic antidepressants, 32 received maprotiline hydrochloride, a tetracyclic compound, 20 received other medications, and 82 received no drug treatment. One patient in the tricyclic group (2.2%) and five patients in the maprotiline group (15.6%) developed seizures. In four patients the seizure followed the institution of maprotiline therapy by less than three weeks. These data indicate that depressed patients taking the tetracyclic drug maprotiline are at risk for developing epileptic seizures.
Author Affiliations
From the Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Md, and the Neurology Service, Walter Reed Army Medical Center, Washington, DC.
Footnotes
Accepted for publication May 23, 1984.
The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of Defense or Uniformed Services University of the Health Sciences.
Reprint requests to Box 310, Walter Reed Army Medical Center, Washington, DC 20307 (Dr Jabbari).
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