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Results of Therapy

Martin J. Murphy, MD

Arch Neurol. 1985;42(5):477-479.

Abstract
• Of 115 patients with angiographically demonstrated cerebral arteriovenous malformations (AVMs), seizures occurred in 66 (57%), all of whom had supratentorial AVMs. Seizures were the initial manifestations in 36 patients. In 14 patients seizures developed within 30 days of hemorrhage or surgical resection; in 16 others seizures started within 0.5 to 16 years after hemorrhage or resection. Seizures were infrequent in the majority of patients; in only nine (16%) were they incapacitating. Among 46 patients observed from two to 36 years, 23 (50%) were seizure free for a minumum of two years at follow-up. Neurological deficits on examination and previous occurrence of hemorrhage did not adversely affect seizure control. No significant difference was found between the percentage of seizure-free patients in the medical and surgical groups at follow-up. Irrespective of treatment method, seizures starting within 30 days of hemorrhage or resection had the best prognosis.

Author Affiliations
From the Department of Neurology, University of Iowa College of Medicine, Iowa City.

Footnotes
Accepted for publication April 16, 1984.

Read in part at the Annual Meeting of the American Epilepsy Society, New York, Dec 4, 1981.

Reprint requests to 9102 Babcock Blvd, Pittsburgh, PA 15237 (Dr Murphy).

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