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Their Use in the Evaluation of Drugs

Anthony Hopkins, MD, FRCP; Philip Davies, MSc; Charles Dobson, PhD

Arch Neurol. 1985;42(5):463-467.

Abstract
• The analysis of the results of many well-designed, double-blind trials of anticonvulsant drugs has been unsophisticated. We draw attention to the nonrandom occurrence of seizures, which negates the simple comparison of average seizure frequency. We propose a method of taking into account clustering of seizures when deciding on the appropriate length of follow-up after introducing a new treatment. Deterministic and nondeterministic models were used to show why there may be reasons for sometimes using more than one drug in the treatment of epilepsy.

Author Affiliations
(London)

From the Department of Neurological Sciences, St Bartholomew's Hospital, London (Dr Hopkins), the Research Centre for the Mathematical Modelling of Clinical Trials, University of Warwick, Coventry, England (Mr Davies), and the Operational Research Services Branch, Department of Health and Social Security, London (Dr Dobson).

Footnotes
Accepted for publication Aug 4, 1984.

Reprint requests to Department of Neurological Sciences, St Bartholomew's Hospital, London, EC1A 7BE, England (Dr Hopkins).

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