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Carol A. Tamminga, MD; Peter A. LeWitt, MD; Thomas N. Chase, MD

Arch Neurol. 1985;42(4):354-355.

Abstract
• In successive samples of human lunbar CSF, concentrations of two neurally active peptides, cholecystokinin (CCK) and neurotensin (NT), were compared with levels of homovanillic acid (HVA), the major metabolite of dopamine. Although HVA values progressively increased between the first and 20th milliliter samples, no significant change occurred in the concentration of either peptide. Thus, lumbar CSF levels of CCK and NT, unlike levels of HVA, may not closely reflect amounts of these peptides in supraspinal CSF or brain.

Author Affiliations
From the Experimental Therapeutics Branch, National Institute of Neurological and Communicative Disorders and Stroke (NINCDS), Bethesda, Md (Drs Tamminga, LeWitt, and Chase), and the Maryland Psychiatric Research Center, University of Maryland, Baltimore (Dr Tamminga).

Footnotes
Accepted for publication May 8, 1984.

Reprint requests to NINCDS, 9000 Rockville Pike, Bldg 10, Room 5C103, Rockville, MD 20205 (Dr Tamminga).

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