This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Ilo E. Leppik, MD; Judy Lapora, RN; Ruth Loewenson, PhD

Arch Neurol. 1985;42(2):120-122.

Abstract
• In a three-year prospective study of patients to whom phenytoin was administered, 26 (8.5%) of 306 patients manifested an erythematous morbiliform rash within three weeks of onset of therapy. Occurrence of the rash was not related to the mode of administration of treatment (loading v maintenance) or initial phenytoin levels. A striking seasonal incidence of the rash was noted: None of the 79 persons who received the initial dose during December to February had a reaction, whereas 13 (20.6%) of 63 persons treated during June to August manifested the rash. For March to May, the rate was 10% (8/88), and for September to November, 6.7% (5/76). Monthly rates were significantly different by ² test.

Author Affiliations
From the Departments of Neurology, University of Minnesota, Minneapolis (Drs Leppik and Loewenson), and St Paul-Ramsey Medical Center, St Paul (Dr Leppik), and the Comprehensive Epilepsy Program, University of Minnesota (Dr Leppik and Ms Lapora).

Footnotes
Accepted for publication March 10, 1984.

Reprint requests to Department of Neurology, St Paul-Ramsey Medical Center, 640 Jackson St, St Paul, MN 55101 (Dr Leppik).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Should People Be Treated After a First Seizure?
Hauser
Arch Neurol 1986;43:1287-1288.
ABSTRACT  

Cerebral Lateralization: Biological Mechanisms, Associations, and Pathology: III. A Hypothesis and a Program for Research
Geschwind and Galaburda
Arch Neurol 1985;42:634-654.
ABSTRACT