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Seasonal Incidence of Phenytoin Allergy Unrelated to Plasma Levels
Ilo E. Leppik, MD;
Judy Lapora, RN;
Ruth Loewenson, PhD
Arch Neurol. 1985;42(2):120-122.
Abstract
In a three-year prospective study of patients to whom phenytoin was administered, 26 (8.5%) of 306 patients manifested an erythematous morbiliform rash within three weeks of onset of therapy. Occurrence of the rash was not related to the mode of administration of treatment (loading v maintenance) or initial phenytoin levels. A striking seasonal incidence of the rash was noted: None of the 79 persons who received the initial dose during December to February had a reaction, whereas 13 (20.6%) of 63 persons treated during June to August manifested the rash. For March to May, the rate was 10% (8/88), and for September to November, 6.7% (5/76). Monthly rates were significantly different by 2 test.
Author Affiliations
From the Departments of Neurology, University of Minnesota, Minneapolis (Drs Leppik and Loewenson), and St Paul-Ramsey Medical Center, St Paul (Dr Leppik), and the Comprehensive Epilepsy Program, University of Minnesota (Dr Leppik and Ms Lapora).
Footnotes
Accepted for publication March 10, 1984.
Reprint requests to Department of Neurology, St Paul-Ramsey Medical Center, 640 Jackson St, St Paul, MN 55101 (Dr Leppik).
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