Severe multicore disease associated with reaction to anesthesia
B. M. Koch, T. E. Bertorini, G. D. Eng and R. Boehm
Multicore disease is a nonprogressive myopathy. To our knowledge, in all
previous cases, the clinical course has been benign with no deaths
attributed to it. We describe a patient who presented as a floppy baby and
remained weaker throughout his life than any other patients previously
described. Biopsy findings were characteristic of multicore disease.
However, at age 21/2 years, our patient developed congestive heart failure
that was easily controlled with digitalis and diuretics. Shortly after
cardiac catheterization, the patient developed a high, unexplained fever
and died 26 hours later despite aggressive attempts at resuscitation.
Therefore, patients with multicores in skeletal muscle may have severe
weakness and may also have a predisposition to complications subsequent to
anesthesia.
