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Norio Tanahashi, MD; John S. Meyer, MD; Yoshiki Ishikawa, MD; Prasab Kandula, MD; Karl F. Mortel, PhD; Robert L. Rogers, PhD; Sunil Gandhi, MD; Mary Walker, MA

Arch Neurol. 1985;42(12):1169-1175.

Abstract
• Brain atrophy estimated by computed tomographic (CT) scanning and mean hemispheric and regional gray matter cerebral blood flow (CBF) values were measured in patients with mild to moderate Huntington's disease (HD) (N = 16) using the xenon Xe 133 inhalation method and in asymptomatic blood relatives at risk from HD (N = 6) using both the xenon Xe 133 inhalation and the stable xenon CT contrast CBF methods. Results were compared with measurements in two groups of age-matched normal volunteers (N = 48 and N = 42, respectively). Significant brain atrophy in the vicinity of both caudate nuclei was present in patients with HD but not in at-risk individuals. Mean hemispheric xenon Xe 133 CBF values were reduced in patients with HD but seemed to be normal in at-risk individuals. In HD, reductions in CBF were found in both frontotemporal regions. Correlations were found between severity of dementia estimated by reductions of Mini-Mental Status Questionnaire scores and reductions of either mean hemispheric or regional frontotemporal CBF values in HD. The CT estimates of brain atrophy and three-dimensional CBF by stable xenon-contrast measurements were normal in asymptomatic individuals at risk from HD.

Author Affiliations
From the Cerebral Blood Flow Laboratories, Veterans Administration Medical Center, Houston (Drs Tanahashi, Meyer, Ishikawa, Kandula, Mortel, Rogers, and Gandhi and Ms Walker); the Departments of Neurology (Drs Tanahashi, Meyer, and Ishikawa) and Radiology (Dr Kandula), Baylor College of Medicine, Houston; and the Department of Psychology, University of Houston (Drs Meyer, Mortel, and Rogers and Ms Walker).

Footnotes
Accepted for publication April 12, 1985.

Reprint requests to Cerebral Blood Flow Laboratories, VA Medical Center, 2002 Holcombe Blvd, Houston, TX 77030 (Dr Meyer).

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