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Margaret L. Grunnet, MD; James O. Donaldson, MD

Arch Neurol. 1985;42(11):1114-1116.

Abstract
• A case of juvenile multisystem degeneration with motor neuron involvement, possibly of familial type, showing many unusual clinical and pathologic features is reported. Eosinophilic intracytoplasmic inclusions were present in some remaining anterior horn cells and motor nerve nuclei of the brain stem as well as in a few neurons of the reticular activating system, the dorsal vagus nuclei, and the intermediolateral cell column. Smaller eosinophilic inclusions were seen in large neurons of the caudate nucleus and putamen, substantia nigra, and subthalamic nucleus.

Author Affiliations
From the Departments of Pathology (Dr Grunnet) and Neurology (Drs Grunnet and Donaldson), University of Connecticut School of Medicine, Farmington.

Footnotes
Accepted for publication Sept 3, 1984.

Reprint requests to Department of Pathology, University of Connecticut Health Center, Farmington, CT 06032 (Dr Grunnet).

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