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The Effect of -9-Tetrahydrocannabinol on Rat Cerebrospinal Fluid

Andrew C. Mancall, MD; G. John DiGregorio, MD, PhD; Charles B. Brill, MD; Eileen Ruch

Arch Neurol. 1985;42(11):1069-1071.

Abstract
• The effect of -9-tetrahydrocannabinol (THC) on cerebrospinal fluid (CSF) flow in rats was studied. The ventricular system of rats anesthetized with ketamine sulfate was cannulated via cisternal puncture, and CSF production was recorded. When administered in doses of 25 mg/kg to 45 mg/kg intraperitoneally, THC caused inhibition of CSF flow; in larger doses a smaller response was noted. In response to THC, CSF flow showed an initial drop, a return toward baseline, and a secondary decrease. It is postulated that this biphasic effect is due to a combination of THC's sympathomimetic effects on the CNS plus the local action that this drug has on choroidal synaptosomal neurotransmitters.

Author Affiliations
From the Departments of Neurology (Drs Mancall and Brill) and Pharmacology (Dr DiGregorio and Ms Ruch), Hahnemann University, Philadelphia.

Footnotes
Accepted for publication March 15, 1985.

Reprint requests to Department of Pharmacology, Hahnemann University, Broad and Vine streets, Philadelphia, PA 19102 (Dr DiGregorio).

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