Cognitive evoked potentials (P300) in early Huntington's disease
C. Rosenberg, K. Nudleman and A. Starr
The P3 component of both auditory-event- and visual-event-related
potentials of 13 patients with Huntington's disease was studied and
compared with the P3 component of normal patients. The latencies of the
patients' P3 components were compared with the latency-age regression lines
generated by the normal population in both modalities. A P3 latency was
considered abnormal if it fell above the 2-SE limit for the latency-age
regression line. The incidence of normal or abnormal P3 latencies in the
two modalities was compared with the results of computed tomography,
electroencephalography, and neuropsychological testing. Nine patients had
abnormal P3 latencies and ten patients had abnormal visual P3 latencies,
with seven having abnormal latencies on both tests and 12 having abnormal
latencies on one of the two tests. An abnormal P3 latency in one modality
did not imply an abnormal P3 latency in the other. An abnormality of the P3
latency did not correlate with an abnormality in results from computed
tomography, electroencephalography, or neuropsychological testing.
