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Their Association With Neuromuscular Diseases, Including the Syndrome of Myalgias/Cramps

Neil L. Rosenberg, MD; Hans E. Neville, MD; Steven P. Ringel, MD

Arch Neurol. 1985;42(10):973-976.

Abstract
• Tubular aggregates of muscle are distinctive structures seen in a wide variety of disorders. We reviewed 1,500 consecutive muscle biopsy specimens for the presence of tubular aggregates. Fifteen biopsy specimens (1.0%) were found with this abnormality. All patients were male, and seven had specific diagnoses based on clinical, biochemical, morphologic, and electrophysiologic criteria: hypokalemic periodic paralysis (two patients); hyperkalemic periodic paralysis (one patient); myotonia congenita (one patient); inflammatory myopathies (three patients). The remaining eight patients had a syndrome characterized predominantly by muscle pain and/or cramps, not necessarily precipitated by exercise. Although tubular aggregates constituted the predominant abnormality on muscle biopsy specimens in these cases, other mild, nonspecific changes were noted.

Author Affiliations
From the Department of Neurology, Neuromuscular Section, University of Colorado School of Medicine (Drs Rosenberg, Neville, and Ringel), and the Neurology Service, Veterans Administration Medical Center (Dr Neville), Denver.

Footnotes
Accepted for publication Oct 1, 1984.

Reprint requests to Box B185, Department of Neurology, University of Colorado School of Medicine, 4200 E Ninth Ave, Denver, CO 80262 (Dr Rosenberg).

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