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Report and Literature Review

Alison Reeve, MD; Sally A. Shulman, MD; Andrew W. Zimmerman, MD; Suzanne B. Cassidy, MD

Arch Neurol. 1985;42(1):69-72.

Abstract
• A 28-year-old mentally retarded man with ring 22 chromosome [r(22)] had deterioration of mood and behavior, decreased speech, bradykinesia, and decline of fine motor skills over a three-year period, which were further exacerbated by treatment with phenothiazines. A trial of methylphenidate hydrochloride resulted in rapid improvement of mood, behavior, and to a small extent, motor function. This finding suggests that dopamine depletion may play a role in the behavioral deterioration seen in this disorder. The possibility that genes that control dopamine metabolism may be present on chromosome 22 is raised. The phenotype of this patient is compared with the 25 reported cases of r(22).

Author Affiliations
From the Departments of Pediatrics (Drs Cassidy and Shulman) and Neurology (Drs Reeve and Zimmerman), University of Connecticut Health Center, Farmington.

Footnotes
Accepted for publication Jan 22, 1984.

Reprint requests to Department of Pediatrics, University of Connecticut Health Center, Farmington, CT 06032 (Dr Cassidy).

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