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  Vol. 42 No. 1, January 1985 TABLE OF CONTENTS
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Propranolol plasma levels and relief of migraine. Relationship between plasma propranolol and 4-hydroxypropranolol concentrations and clinical effects

P. Cortelli, T. Sacquegna, F. Albani, A. Baldrati, R. D'Alessandro, A. Baruzzi and E. Lugaresi

The relationship between propranolol and 4-hydroxypropranolol plasma concentrations and relief of migraine was assessed in 17 patients during treatment with oral racemic propranolol hydrochloride in doses of 40 to 240 mg/day. Propranolol decreased the migraine index more than 70% in 13 patients: five patients at a dosage of 40 mg/day, five patients at a dosage of 120 mg/day, and three patients at a dosage of 240 mg/day. Three patients did not achieve a good improvement of migraine at any of the doses used. The relief of migraine was not directly related to the propranolol and 4-hydroxypropranolol plasma concentrations.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Propranolol modulates trigeminovascular responses in thalamic ventroposteromedial nucleus: a role in migraine?
Shields and Goadsby
Brain 2005;128:86-97.
ABSTRACT | FULL TEXT  





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