 |
|
Propranolol Plasma Levels and Relief of MigraineRelationship Between Plasma Propranolol and 4-Hydroxypropranolol Concentrations and Clinical Effects
Pietro Cortelli, MD;
Tommaso Sacquegna, MD;
Fiorenzo Albani, MD;
Anna Baldrati, MD;
Roberto D'Alessandro, MD;
Agostino Baruzzi, MD;
Elio Lugaresi, MD
Arch Neurol. 1985;42(1):46-48.
Abstract
• The relationship between propranolol and 4-hydroxypropranolol plasma concentrations and relief of migraine was assessed in 17 patients during treatment with oral racemic propranolol hydrochloride in doses of 40 to 240 mg /day. Propranolol decreased the migraine index more than 70% in 13 patients: five patients at a dosage of 40 mg/day, five patients at a dosage of 120 mg/day, and three patients at a dosage of 240 mg/ day. Three patients did not achieve a good improvement of migraine at any of the doses used. The relief of migraine was not directly related to the propranolol and 4-hydroxypropranolol plasma concentrations.
Author Affiliations
From the Headache Center, Institute of Neurology, University of Bologna, Bologna, Italy.
Footnotes
Accepted for publication March 20, 1984.
Reprint requests to Clinica Neurologica, Universitá di Bologna, Via Ugo Foscolo 7, 40123 Bologna, Italy (Dr Cortelli).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Propranolol modulates trigeminovascular responses in thalamic ventroposteromedial nucleus: a role in migraine?
Shields and Goadsby
Brain 2005;128:86-97.
ABSTRACT
| FULL TEXT
Propranolol in Prophylaxis of Migraine-Reply
Ziegler
Arch Neurol 1994;51:1182-1182.
ABSTRACT
Propranolol in Prophylaxis of Migraine
Cortelli and Albani
Arch Neurol 1994;51:1181-1182.
ABSTRACT
|
