Chediak-Higashi syndrome. Neurologic appearance
R. E. Pettit and K. G. Berdal
A 25-year-old man was first seen with a neurologic disorder that resembled
a spinocerebellar degeneration and parkinsonism. A peripheral smear
revealed the characteristic peroxidase-positive panleukocytic granules
associated with the Chediak-Higashi syndrome. He did not have any
associated oculocutaneous abnormalities. The Chediak-Higashi syndrome may
appear primarily with neurologic dysfunction and should be considered in a
differential diagnosis of children and young adults first seen with a
spinocerebellar degeneration or movement disorder.
