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Geoffrey J. Gorse, MD; Lewis M. Slater, MD; Efim Sobol, MD; Ronald C. Kim, MD; Rodney M. Wishnow, MD; Thomas C. Cesario, MD

Arch Neurol. 1984;41(8):882-884.

Abstract
• Central nervous system infection with Clostridium septicum is rare. We report two fulminant cases of such infection with accompanying bacteremia. The presence of extensive brain necrosis was striking in our two cases. The association of C septicum bacteremia with hematologic disease, and with solid tumors, was present in our cases. We conclude that C septicum should be considered as a potential cause of life-threatening bacteremia and meningitis in the compromised host.

Author Affiliations
From the Divisions of Infectious Disease (Drs Gorse and Cesario) and Hematology and Oncology (Dr Slater), Department of Medicine, University of California-Irvine Medical Center, Orange, and the Laboratory Service (Drs Sobol and Kim) and Department of Infectious Disease (Dr Wishnow), Long Beach (Calif) Veterans Administration Medical Center. Dr Gorse is now with the Marshall University School of Medicine, Huntington, WVa.

Footnotes
Accepted for publication Aug 13, 1983.

Reprint requests to Section of Infectious Disease, Department of Medicine, Marshall University School of Medicine, Huntington, WV 25701 (Dr Gorse).

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