Effect of a single brief seizure on subsequent seizure susceptibility in the immature rat
G. L. Holmes, B. J. Albala and S. L. Moshe
To determine whether a single seizure permanently affects the brain's
susceptibility to further seizures, 27-day-old rats were subjected to a
single seizure induced by either an electroshock or the administration of
pentylenetetrazol. Three days following the seizure, the rats, along with
age- and weight-matched control rats, underwent kindling. The rate of
kindling did not differ between the control rats and those rats that had
previously experienced a single electroshock or pentylenetetrazol-induced
seizure. At the present time, there is no conclusive evidence that a single
brief seizure results in permanently increased susceptibility to future
convulsions.