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Communicating Hydrocephalus and Lysosomal Inclusions in Mannosidosis
John J. Halperin, MD;
Dennis M. D. Landis, MD;
Lori A. Weinstein;
Ira T. Lott, MD;
Edwin H. Kolodny, MD
Arch Neurol. 1984;41(7):777-779.
Abstract
A 32-year-old man with mannosidosis had a gait disorder develop that was associated with communicating hydrocephalus. The gait disorder improved with ventriculoperitoneal shunting, but proximal muscle weakness remained. Biopsy specimens of muscle and nerve disclosed typical lysosomal inclusions in both tissues, as well as selective loss of unmyelinated axons.
Author Affiliations
From the Neurology Service, Massachusetts General Hospital, Boston, and the Eunice Kennedy Shriver Center, Waltham, Mass. Dr Halperin is now with the Health Sciences Center, State University of New York (SUNY) at Stony Brook, and Dr Lott is now with the University of California Medical Center at Irvine.
Footnotes
Accepted for publication Sept 15, 1983.
Read in part before the 34th annual meeting of the American Academy of Neurology, Washington, DC, April 30, 1982.
Reprint requests to Department of Neurology, Health Sciences Center, SUNY at Stony Brook, Stony Brook, NY 11794 (Dr Halperin).
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