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Harvey S. Singer, MD; Leslie Oshida, MS; Joseph T. Coyle, MD

Arch Neurol. 1984;41(7):756-757.

Abstract
• Cerebrospinal fluid acetylcholinesterase (AChE) activity was studied as a possible marker for central cholinergic neuronal function in seven patients with Gilles de la Tourette's syndrome. No significant differences were found between CSF AChE activity in untreated or haloperidol-treated patients and control populations. These data do not appear to support a pathophysiologic association between the cholinergic system and Gilles de la Tourette's syndrome.

Author Affiliations
From the Departments of Neurology (Dr Singer), Pediatrics (Drs Singer and Coyle), Neuroscience (Ms Oshida and Dr Coyle), and Psychiatry (Dr Coyle), Johns Hopkins University School of Medicine, Baltimore.

Footnotes
Accepted for publication Aug 13, 1983.

Reprint requests to Department of Neurology, Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21205 (Dr Singer).

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ABSTRACT