This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (12)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Robert ten Houten, MD; Marianne De Visser, MD

Arch Neurol. 1984;41(7):729-733.

Abstract
• Muscle biopsy specimens from 14 patients with Becker-type muscular dystrophy were analyzed to investigate possible neurogenic factors underlying the histopathological changes. Group atrophy, pyknotic nuclear clumps, and angular small fibers were seen respectively in 71%, 85%, and 100% of the cases. In one biopsy specimen, notable type grouping was observed. A prominent finding was the appearance of groups of regenerating fibers in biopsy specimens from younger patients. Fiber degeneration was present in only 57% of the cases. While myopathic features predominated in some biopsy specimens, others were compatible with denervation. It is not possible to give an answer to the question whether the changes are basically myopathic or neurogenic (or both), but evidence is growing that a neurogenic component may play a part in the pathogenesis of the disease.

Author Affiliations
From the Muscle Research Center of the Neurological Department, University Hospital, University of Amsterdam, the Netherlands. Dr ten Houten is now with the University Hospital, State University of Groningen, the Netherlands.

Footnotes
Accepted for publication Sept 11, 1983.

Reprint requests to Neurological Department, University Hospital, Oostersingel 59, 9713 EZ Groningen, the Netherlands (Dr ten Houten).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?