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Tremor as a Feature of Chronic Relapsing and Dysgammaglobulinemic PolyneuropathiesIncidence and Management
Marinos C. Dalakas, MD;
Heikki Teräväinen, MD;
W. King Engel, MD
Arch Neurol. 1984;41(7):711-714.
Abstract
Seven patients with chronic relapsing polyneuropathy and four patients with dysgammaglobulinemic polyneuropathy had tremor during the course of their illness. The tremor was coarse, irregular, and unrelated to proprioception loss, muscle weakness, or fatigue; it appeared to represent disease activity or an early sign of a new relapse. None of these patients had clinical signs of CNS disease or family history of essential tremor. The tremor in all seven patients with relapsing neuropathy and in one of the three treated patients with dysgammaglobulinemia responded to immunosuppressive drugs that controlled the underlying immune mechanism(s) of the disease. In two patients with dysgammaglobulinemic polyneuropathy, the tremor improved with propranolol hydrochloride.
Author Affiliations
From the Neuromuscular Diseases Section, Medical Neurology Branch, National Institutes of Health, Bethesda, Md.
Footnotes
Accepted for publication Sept 15, 1983.
Reprint requests to Bldg 36, Room 5D-06, National Institute of Neurological and Communicative Diseases and Stroke, NIH, Bethesda, MD 20205 (Dr Dalakas).
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