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 -Aminobutyric Acid and Homovanillic Acid Concentration in the CSF of Patients With Senile Dementia of Alzheimer's Type
Reinhilde Zimmer, MD;
Albert W. Teelken, MD;
Wilhelm B. Trieling;
Werner Weber, MD;
Thomas Weihmayr;
Hans Lauter, MD
Arch Neurol. 1984;41(6):602-604.
Abstract
• The investigation of enzyme and neurotransmitter levels and/or their metabolites in the CSF of patients with senile dementia of Alzheimer's type (SDAT) could become a promising approach for a clinical research and diagnostic procedure. To learn more about the metabolic reflections of central metabolism in the CSF of patients with SDAT, we measured CSF levels of  -aminobutyric acid (GABA) and homovanillic acid (HVA), the dopamine metabolite. In 16 female patients with SDAT and in eight matched control patients, CSF GABA levels were measured by ion exchange with fluorimetric detection, and HVA levels were measured fluorimetrically. The GABA content of the CSF was significantly reduced in patients with SDAT, whereas the HVA level was unchanged.
Author Affiliations
From the Psychiatric Hospital of the Technical University of Munich (Dr Zimmer, Mr Weihmayr, and Dr Lauter); the Department of Biochemistry of the Neurological Hospital of the University of Groningen, the Netherlands (Dr Teelken and Mr Trieling); and the Institute of Anesthesiology of the University of Munich (Dr Weber).
Footnotes
Accepted for publication Aug 13, 1983.
Reprint requests to Psychiatrische Klinik des Klinikums rechts der Isar der TU München, Möhlstrasse 26, D-8000 München 80, West Germany (Dr Zimmer).
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