Abetalipoproteinemia and metastatic spinal cord glioblastoma
R. P. Newman, E. J. Schaefer, C. B. Thomas and E. H. Oldfield
Abetalipoproteinemia (ABL [Bassen-Kornzweig syndrome]) is characterized by
marked hypolipidemia with absence of low-density lipoproteins, fat-soluble
vitamin deficiency, spinocerebellar ataxia, and retinitis pigmentosa. Our
patient had ABL, severe neurologic disease, and spinal cord malignancy, as
well as disseminated CNS and extraneural metastases. It is possible that
patients with this disorder and long-standing fat-soluble vitamin
deficiency may have increased risk for CNS malignancy.