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  Vol. 41 No. 5, May 1984 TABLE OF CONTENTS
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Abetalipoproteinemia and Metastatic Spinal Cord Glioblastoma

Richard P. Newman, MD; Ernst J. Schaefer, MD; Christine B. Thomas, MD; Edward H. Oldfield, MD

Arch Neurol. 1984;41(5):554-556.


Abstract



• Abetalipoproteinemia (ABL [Bassen-Kornzweig syndrome]) is characterized by marked hypolipidemia with absence of low-density lipoproteins, fat-soluble vitamin deficiency, spinocerebellar ataxia, and retinitis pigmentosa. Our patient had ABL, severe neurologic disease, and spinal cord malignancy, as well as disseminated CNS and extraneural metastases. It is possible that patients with this disorder and long-standing fat-soluble vitamin deficiency may have increased risk for CNS malignancy.



Author Affiliations



From the Experimental Therapeutics (Dr Newman) and Surgical Neurology (Dr Oldfield) Branches, National Institute of Neurological and Communicative Disorders and Stroke, the Molecular Disease Branch, National Heart, Lung, and Blood Institute (Dr Schaefer), and the Laboratory of Clinical Pathology, National Cancer Institute (Dr Thomas), National Institutes of Health, Bethesda, Md.


Footnotes



Accepted for publication June 16, 1983.

Reprint requests to Experimental Therapeutics Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bldg 10, Room 5 C-103, 9000 Rockville Pike, Bethesda, MD 20205 (Dr Newman).



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