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Masanori Igarashi, MD; Richard C. Gilmartin, MD; Barry Gerald, MD; Frank Wilburn, MD; J. T. Jabbour, MD

Arch Neurol. 1984;41(5):531-535.

Abstract
• Twelve cases of large- and mediumsized cerebral artery stenosis and/or occlusion associated with bacterial meningitis occurred. Neurological complication due to arterial involvement developed in seven patients on the third and fourth days of illness; in one patient, it developed on the fifth day, and in another it developed on the 14th day. In three cases, this could not be determined. Arterial stenosis is considered primarily to result from arterial spasm due to humoral factors that may be elaborated within the CSF or arterial wall, as in the cases of ruptured aneurysm; and secondarily, from to inflammatory involvement of major vessels at the base of the brain and from irritation by angiographic contrast material.

Author Affiliations
From the Departments of Pediatrics (Drs Igarashi, Gilmartin, Wilburn, and Jabbour), Neurology (Drs Igarashi, Gilmartin, and Jabbour), and Diagnostic Radiology (Dr Gerald), University of Tennessee Center for the Health Sciences, LeBonheur Children's Medical Center, and Frank Tobey Children's Hospital, Memphis.

Footnotes
Accepted for publication July 10, 1983.

Reprint requests to Department of Pediatric Neurology, LeBonheur Children's Medical Center, 848 Adams St, Memphis, TN 38103 (Dr Igarashi).

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