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Quantitative Axon Terminal and End-plate Morphology in Amyotrophic Lateral Sclerosis
Elizabeth K. Bjornskov, MA;
Forbes H. Norris, Jr, MD;
Janis Mower-Kuby, PhD
Arch Neurol. 1984;41(5):527-530.
Abstract
• An axon-end-plate double stain yielded more synaptic detail than the older methylene blue stain of the muscle biopsy specimen. Application of the double stain to amyotrophic lateral sclerosis confirmed earlier and well-known findings of denervation, abnormal end-plates, and axonal sprouting. Little new data emerged, however, and the sprouting index seemed to mislead. As in several previous investigations, muscle from normal human subjects showed evidence for at least past if not current denervation, substantiating the need for continued rigorous controls in such studies.
Author Affiliations
From the ALS and Neuromuscular Research Center, and the Medical Research Institute of San Francisco, Pacific Medical Center (Ms Bjornskov and Dr Norris), and the Department of Biology, San Francisco State University (Dr Mower-Kuby).
Footnotes
Accepted for publication July 14, 1983.
Presented at the Fifth International Congress on Neuromuscular Diseases, Marseilles, France, Sept 15, 1982.
Reprint requests to ALS and Neuromuscular Research Center, Pacific Medical Center, Box 7999, San Francisco, CA 94120 (Dr Norris).
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