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Roger E. Kelley, MD; Paul B. Gilman, MD; Andrew G. Kovacs, MD

Arch Neurol. 1984;41(5):521-523.

Abstract
• Two patients with manifestations of cerebral ischemia were found to have a circulating coagulation inhibitor. This immunoglobulin, termed lupus anticoagulant, results in a prolonged partial thromboplastin time. Paradoxically, it is usually associated with a thrombotic tendency rather than a bleeding diathesis. It is most commonly found in systemic lupus erythematosus, which our patients did not have. These two patients represent the interesting phenomenon of cerebral ischemia in the presence of an endogenous inhibitor of coagulation.

Author Affiliations
From the Department of Neurology (Drs Kelley and Kovacs), Temple University Hospital and the Cardeza Foundation for Hematologic Research, and the Department of Medicine (Dr Gilman), Jefferson Medical School, Philadelphia. Dr Kelley is currently affiliated with the University of Miami School of Medicine.

Footnotes
Accepted for publication July 14, 1983.

Reprint requests to University of Miami School of Medicine (D4-5), PO Box 016960, 1501 NW Ninth Ave, Miami, FL 33101 (Dr Kelley).

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ABSTRACT