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Patients With Multiple Sclerosis Experience Hearing Loss Specifically for Shifts of Tone Frequency
Douglas B. Quine, PhD;
David Regan, PhD, DSc;
Kenneth I. Beverley, PhD;
Thomas J. Murray, MD, FRCP(C)
Arch Neurol. 1984;41(5):506-508.
Abstract
• After exposure to a prolonged tone of changing intensity but constant frequency, controls, patients with peripheral hearing loss, and patients with multiple sclerosis (MS) demonstrated a reduced sensitivity to shifts in intensity; sensitivity to frequency shifts was unaffected. After exposure to a prolonged tone of changing frequency but constant intensity, control and patients with peripheral hearing loss demonstrated reduced sensitivity to shifts in frequency; sensitivity to intensity shifts was unaffected. Some patients with MS showed no loss of sensitivity to shifts in frequency. Our findings suggest that some patients with MS have abnormal mechanisms for processing changes of frequency. If such processing of frequency change is important for understanding speech, then this observation of a specific central hearing defect may help to explain poor speech discrimination in some patients with MS who have normal audiograms.
Author Affiliations
From the Departments of Physiology/Biophysics (Drs Quine, Regan, and Beverley), Otolaryngology (Drs Quine and Regan), and Medicine (Dr Murray), Dalhousie University, Halifax, Nova Scotia. Dr Quine is now at Tulane Medical School, New Orleans.
Footnotes
Accepted for publication June 11, 1983.
Read in part before the Acoustical Society of America, Ottawa, May 1981.
Reprint requests to Gerard Hall, 5303 Morris St, Halifax, Nova Scotia, Canada B3J 1B6 (Dr Regan).
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