Human cytomegalovirus infection and disorders of the nervous system
J. F. Bale Jr
Infection with human cytomegalovirus (CMV) occurs in nearly 1% of live-born
infants, and from 60% to 80% of the inhabitants of the United States
acquire CMV infection by mid adulthood. While neurologic disorders do not
develop in the majority of congenitally infected infants, congenital CMV
infection can severely damage the developing nervous system, causing
microcephaly, psychomotor retardation, seizures, and deafness. Furthermore,
approximately 10% of infants who are asymptomatic at birth subsequently
exhibit sensorineural hearing loss. In the adult, CMV infection has been
associated with the Guillain-Barre syndrome, meningoencephalitis, and
retinitis. Although Guillain-Barre syndrome can accompany CMV infections in
previously healthy adults, meningoencephalitis and retinitis occur more
commonly in immunosuppressed patients, particularly among organ transplant
recipients. In total, at least 7,000 persons in the United States each year
have neurologic disorders attributable to CMV infection.
Neonatal Neural Progenitor Cells and Their Neuronal and Glial Cell Derivatives Are Fully Permissive for Human Cytomegalovirus Infection
Luo et al.
J. Virol. 2008;82:9994-10007.
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Long-Term Infection and Shedding of Human Cytomegalovirus in T98G Glioblastoma Cells
Luo and Fortunato
J. Virol. 2007;81:10424-10436.
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Human cytomegalovirus inhibits neuronal differentiation and induces apoptosis in human neural precursor cells.
Odeberg et al.
J. Virol. 2006;80:8929-8939.
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Innate Immune Responses to Cytomegalovirus Infection in the Developing Mouse Brain and Their Evasion by Virus-Infected Neurons
Kosugi et al.
Am. J. Pathol. 2002;161:919-928.
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Reactivation of Latent Cytomegalovirus Infection in Mouse Brain Cells Detected after Transfer to Brain Slice Cultures
Tsutsui et al.
J. Virol. 2002;76:7247-7254.
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Murine Cytomegalovirus Immediate-Early Promoter Directs Astrocyte-Specific Expression in Transgenic Mice
Aiba-Masago et al.
Am. J. Pathol. 1999;154:735-743.
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Congenital Lymphocytic Choriomeningitis Virus Syndrome: A Disease That Mimics Congenital Toxoplasmosis or Cytomegalovirus Infection
Wright et al.
Pediatrics 1997;100:e9-e9.
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Neuroradiographic Findings in the Newborn Period and Long-term Outcome in Children With Symptomatic Congenital Cytomegalovirus Infection
Boppana et al.
Pediatrics 1997;99:409-414.
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Progressive Encephalopathy Associated With Cytomegalovirus Infection Without Immune Deficiency
Koeda et al.
J Child Neurol 1993;8:373-377.
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Outcome in Children With Symptomatic Congenital Cytomegalovirus Infection
Bale et al.
J Child Neurol 1990;5:131-136.
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