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Arthur K. Shapiro, MD; Miron Baron, MD; Elaine Shapiro, PhD; Morton Levitt, PhD

Arch Neurol. 1984;41(3):282-285.

Abstract
• Activity levels of platelet monoamine oxidase (MAO), plasma amine oxidase (PAO), erythrocyte catechol-o-methyltransferase, and dopamine-β-hydroxylase were measured in 24 drug-free patients with Tourette's syndrome (TS) and in 24 normal control subjects matched for age and sex. Only MAO and PAO activity levels were significantly higher in patients than in controls. Activity of the four enzymes was uncorrelated with age, sex, age of onset of illness, severity of illness, family history of tics and Ts, and ethnic-religious background. The hypothesis that probands with heavily loaded pedigrees or with Ashkenazi ethnic-religious back-ground would be more biochemically deviant was not supported.

Author Affiliations
From the Tourette and Tic Laboratory and Clinic, Mount Sinai Medical Center, New York (Drs A. and E. Shapiro); New York State Psychiatric Institute, New York, and Columbia University College of Physicians and Surgeons, New York (Drs Baron and Levitt).

Footnotes
Accepted for publication June 8, 1983.

Reprint requests to Tourette and Tic Laboratory and Clinic, Mount Sinai School of Medicine, Annenberg Building, Room 22-72, 1 Gustave L. Levy PI, New York, NY 10029 (Dr A. Shapiro).

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