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Eric H. Denys, MD; James E. Jackson, MA; Mary Jane Aguilar, MD; Andrew J. Wilson, MD; Forbes H. Norris, MD

Arch Neurol. 1984;41(2):161-163.

Abstract
• To test the hypothesis that a serum factor might play a role in the pathogenesis of amyotrophic lateral sclerosis, whole plasma obtained by plasmapheresis from patients with the disease was injected daily intraperitoneally into mice for periods of up to three months. Similar experiments were carried out with an isolated immunoglobulin fraction. Control experiments were carried out simultaneously. The animals were tested electrophysiologically, and histologic examinations of the brain, spinal cord, and peripheral nerves were performed. No ill effects were noted in the animals, and no neurophysiologic or microscopic abnormalities were detected.

Author Affiliations
From the ALS and Neuromuscular Research Center and the Institute of Neurological Sciences, Medical Research Institute of San Francisco, Pacific Medical Center, San Francisco.

Footnotes
Accepted for publication May 30, 1983.

Reprint requests to ALS and Neuromuscular Research Center, Pacific Medical Center, 2351 Clay St, Stanford 416, San Francisco, CA 94115 (Dr Denys).

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ABSTRACT