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David B. Clifford, MD; John L. Trotter, MD

Arch Neurol. 1984;41(12):1270-1272.

Abstract
• We reviewed 317 patients with multiple sclerosis (MS) and found that the incidence of clinically significant pain, excluding headache and paresthesia, was 28.8%. Successful treatment requires recognition of the pathophysiology of the pain syndromes encountered in MS. Antidepressant drugs have been of particular value in the treatment of chronic pain in these patients.

Author Affiliations
From the Department of Neurology and Neurological Surgery (Drs Clifford and Trotter) and the Division of Clinical Neuropharmacology (Dr Clifford), Washington University School of Medicine, St Louis.

Footnotes
Accepted for publication Jan 18, 1984.

Reprint requests to Department of Neurology and Neurological Surgery, Washington University School of Medicine, Box 8111, 660 S Euclid Ave, St Louis, MO 63110 (Dr Clifford).

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