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Clinical Relevance

Michael J. Aminoff, MD; Suzanne L. Davis, MB, ChB; Hillel S. Panitch, MD

Arch Neurol. 1984;41(11):1197-1202.

Abstract
• Twelve patients with clinically definite multiple sclerosis were examined both clinically and electrophysiologically at repeated intervals over one year to determine the clinical relevance of data obtained by serial multimodality evoked potential studies. We frequently found a disparity between the clinical and electrophysiologic changes, and also an excessive variability between test sessions of the responses to stimulation of a clinically involved afferent pathway even when the clinical deficit was stable. Our findings indicate that though evoked potential studies may provide information of diagnostic relevance, their role in monitoring disease progression has not been established.

Author Affiliations
From the Department of Neurology, School of Medicine, University of California, San Francisco.

Footnotes
Accepted for publication Nov 16, 1983.

Reprint requests to Room 794-M, Department of Neurology, University of California, San Francisco, CA 94143 (Dr Aminoff).

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