Serial evoked potential studies in patients with definite multiple sclerosis. Clinical relevance
M. J. Aminoff, S. L. Davis and H. S. Panitch
Twelve patients with clinically definite multiple sclerosis were examined
both clinically and electrophysiologically at repeated intervals over one
year to determine the clinical relevance of data obtained by serial
multimodality evoked potential studies. We frequently found a disparity
between the clinical and electrophysiologic changes, and also an excessive
variability between test sessions of the responses to stimulation of a
clinically involved afferent pathway even when the clinical deficit was
stable. Our findings indicate that though evoked potential studies may
provide information of diagnostic relevance, their role in monitoring
disease progression has not been established.
