Serum creatine kinase B concentrations in acute cerebrovascular diseases
F. E. Pfeiffer, H. A. Homburger and T. Yanagihara
Serum creatine kinase B (CKB) concentrations were measured every 12 hours
for five days in 38 patients during acute cerebrovascular diseases and in
nine controls. Mean CKB concentration was 6.2 +/- 0.8 ng/mL. The
fluctuation of the CKB concentration following ischemic stroke was as
notable as the elevation immediately after the ischemic event. The two
abnormalities were observed in 13 of 17 patients with acute cerebral
infarction, and the extent of abnormalities roughly correlated with the
volume of tissue damage. The profiles were normal for patients with
transient vascular events. Patients with subarachnoid hemorrhage
demonstrated wide fluctuation along with high CKB concentration. Although
transient elevation of the CKB concentration in some patients with
subarachnoid hemorrhage was observed after angiography or clinical
worsening, the fluctuation in patients with ischemic stroke was not
associated with worsening of neurologic conditions or recurrence of
ischemic events.
