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Shlomo Flechter, MD; Jacob Vardi, MD; Israel Just, MD; Ruth Arnon, PhD; Dvora Teitelbaum, PhD

Arch Neurol. 1984;41(11):1158-1160.

Abstract
• Chronic relapsing experimental allergic encephalomyelitis (EAE) was induced in young Dunkin Hartley guinea pigs by a single sensitization with guinea pig spinal cord homogenate. The effect of either newborn thymectomy or young adult thymectomy on the clinical course of chronic and relapsing EAE was studied and evaluated statistically by Student's t test. All the animals that underwent thymectomy showed a significant delay in the onset of the disease compared with control groups. In addition, in the young adult guinea pigs in which thymectomy was done, the incidence of clinical disease was decreased. No substantial differences, however, were observed in the severity of the disease and number of remissions or relapses between guinea pigs in which thymectomy was done and in which clinical symptoms developed and controls.

Author Affiliations
From the Departments of Neurology, Assaf-Harofeh Medical Center, Zerifin, Israel (Drs Flechter and Vardi), Medicine "B," Municipal Governmental Medical Center, Ichilow Hospital, Tel-Aviv (Dr Just), and Chemical Immunology, Weizman Institute of Science, Rehovot, Israel, (Drs Arnon and Teitelbaum).

Footnotes
Accepted for publication Dec 15, 1983.

Reprint requests to Department of Neurology, Assaf-Harofeh Medical Center, 70350 Zerifin, Israel (Dr Flechter).

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