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Reaction Time and Vigilance in Parkinson's DiseasePossible Role of Altered Norepinephrine Metabolism
Yaakov Stern, PhD;
Richard Mayeux, MD;
Lucien Côté, MD
Arch Neurol. 1984;41(10):1086-1089.
Abstract
• Delayed reaction time and diminished vigilance have been observed in Parkinson's disease (PD) but have not been related to biochemical changes in the disease. As norepinephrine is reduced in the brain in PD and this neurotransmitter has been related to attention and learning, we investigated the relationship of neuropsychological measures, including those of reaction time and vigilance, to the norepinephrine metabolite 3- methoxy - 4 - hydroxyphenethyleneglycol (MHPG) in 39 patients with idiopathic PD. The MHPG levels correlated with a measure of general intellectual ability and with performance on reaction time and continuous performance tasks. Our data suggest that altered norepinephrine metabolism may contribute to some aspects of intellectual dysfunction in PD.
Author Affiliations
From the Departments of Neurology (Drs Stern, Mayeux, and Côté) and Rehabilitation Medicine (Dr Côté), Columbia University College of Physicians and Surgeons, New York.
Footnotes
Accepted for publication Jan 27, 1984.
Presented in part before the 35th annual meeting of the American Academy of Neurology, April 28, 1983, San Diego.
Reprint requests to 710 W 168th St, New York, NY 10032 (Dr Mayeux).
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