This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

An Epidemiologic Study

Randolph B. Schiffer, MD; Haroutun M. Babigian, MD

Arch Neurol. 1984;41(10):1067-1069.

Abstract
• Certain CNS diseases can produce specific behavioral abnormalities. We used a computer search technique to identify all inpatients at Strong Memorial Hospital, Rochester, NY, who had received diagnoses of multiple sclerosis (MS), temporal lobe epilepsy (TLE), and amyotrophic lateral sclerosis (ALS) between 1965 and 1978. We found 368 patients with MS, 402 patients with TLE, and 124 patients with ALS. These groups were matched against the Monroe County (New York) Psychiatric Register to determine patterns of behavioral pathology. Prevalence rates for psychiatric contact were not significantly different between MS and TLE (19.3% v 22.9%), but both were higher than the prevalence rate for ALS (4.8%). When behavioral patterns were assessed, patients with MS demonstrated a significantly higher rate of depressed affective disorders (61.97% of register matches) than patients with the other two diseases. Multiple sclerosis may present a neurologic model for mood disturbance.

Author Affiliations
From the Departments of Psychiatry (Drs Schiffer and Babigian) and Neurology (Dr Schiffer), Strong Memorial Hospital, Rochester, NY.

Footnotes
Accepted for publication Dec 2, 1983.

Reprint requests to Departments of Psychiatry and Neurology, Strong Memorial Hospital, 300 Crittenden Blvd, Rochester, NY 14642 (Dr Schiffer).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Introduction to Best practice recommendations for the selection and management of patients with MS on natalizumab
Munschauer et al.
Mult Scler 2009;15:S1-S6.
 

Antidepressant use in multiple sclerosis: epidemiologic study of a large community sample
Cetin et al.
Mult Scler 2007;13:1046-1053.
ABSTRACT  

One question as a screening instrument for depression in people with multiple sclerosis
Vahter et al.
Clin Rehabil 2007;21:460-464.
ABSTRACT  

Cognitive Predictors of Response to Treatment for Depression in Multiple Sclerosis
Julian and Mohr
J. Neuropsychiatry Clin. Neurosi. 2006;18:356-363.
ABSTRACT | FULL TEXT  

The Goldman Consensus statement on depression in multiple sclerosis
Goldman Consensus Group
Mult Scler 2005;11:328-337.
ABSTRACT  

[11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS
Turner et al.
Brain 2005;128:896-905.
ABSTRACT | FULL TEXT  

Major depression in multiple sclerosis: A population-based perspective
Patten et al.
Neurology 2003;61:1524-1527.
ABSTRACT | FULL TEXT  

Analyses of nursing home residents with multiple sclerosis and depression using the Minimum Data Set
Buchanan et al.
Mult Scler 2003;9:171-188.
ABSTRACT  

Depressive Symptoms and Severity of Illness in Multiple Sclerosis: Epidemiologic Study of a Large Community Sample
Chwastiak et al.
Am. J. Psychiatry 2002;159:1862-1868.
ABSTRACT | FULL TEXT  

The relationship between disability and depression in multiple sclerosis: the role of uncertainty, coping, and hope
Lynch et al.
Mult Scler 2001;7:411-416.
ABSTRACT  

Psychotic Depression: An Atypical Initial Presentation of Multiple Sclerosis
Clarke et al.
Psychosomatics 1998;39:72-75.
FULL TEXT  

Mood Disorders and Dysfunction of the Hypothalamic-Pituitary-Adrenal Axis in Multiple Sclerosis: Association With Cerebral Inflammation
Fassbender et al.
Arch Neurol 1998;55:66-72.
ABSTRACT | FULL TEXT  

Multiple sclerosis, depression, and suicide
Feinstein
BMJ 1997;315:691-692.
FULL TEXT  

Psychological aspects of motor neurone disease: a review
Worthington
Clin Rehabil 1996;10:185-194.
 

What Do We Really Know About Cognitive Dysfunction, Affective Disorders, and Stress in Multiple Sclerosis? A Practitioner's Guide
Fischer et al.
Neurorehabil Neural Repair 1994;8:151-164.
ABSTRACT  

A Prospective Study of Depression and Immune Dysregulation in Multiple Sclerosis
Foley et al.
Arch Neurol 1992;49:238-244.
ABSTRACT  

Affective Disorders in Multiple Sclerosis Review and Recommendations for Clinical Research
Minden and Schiffer
Arch Neurol 1990;47:98-104.
ABSTRACT  

A Comparison of Dementia in Alzheimer's Disease and Multiple Sclerosis
Filley et al.
Arch Neurol 1989;46:157-161.
ABSTRACT  

Cognitive Loss in Multiple Sclerosis: Case Reports and Review of the Literature
Franklin et al.
Arch Neurol 1989;46:162-167.
ABSTRACT  

The Spectrum of Depression in Multiple Sclerosis: An Approach for Clinical Management
Schiffer
Arch Neurol 1987;44:596-599.
ABSTRACT  

Mood Disorder and Multiple Sclerosis
Joffe et al.
Arch Neurol 1987;44:376-378.
ABSTRACT  

Temporal Lobe Involvement in Multiple Sclerosis Patients With Psychiatric Disorders
Honer et al.
Arch Neurol 1987;44:187-190.
ABSTRACT  

Multiple Sclerosis and Depression
Kronfol
Arch Neurol 1985;42:310-310.
ABSTRACT