Cerebral perfusion imaging with iodine 123-labeled amines
B. L. Holman, T. C. Hill, J. F. Polak, R. G. Lee, H. D. Royal and D. H. O'Leary
Two amines, N-isopropyl p-iodoamphetamine and
N,N,N'-trimethyl-N'-[2-hydroxyl-3-methyl-5-iodobenzyl]-1,3-prop anediamine,
have been labeled with iodine 123. The brain uptake of these radioactive
tracers is proportional to cerebral blood flow. These tracers are retained
in the brain for a sufficiently long time so that imaging can be performed
with standard, readily available instrumentation. Transaxial tomography
with amines is useful in acute cerebral infarction, in which the x-ray
computed tomographic scan may be normal for several days after onset of
symptoms while the uptake of radioisotope-labeled amines will be altered
immediately after the onset of the stroke. It is also useful in examining
patients with cerebral vascular disease and in the preoperative examination
of patients with partial epilepsy.
