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Patterns of Muscle Fiber-Type Disproportion in Hypotonic Infants
Zohar Argov, MD;
David Gardner-Medwin, MD;
Margaret A. Johnson, PhD;
Frank L. Mastaglia, MD
Arch Neurol. 1984;41(1):53-57.
Abstract
• We studied the histochemical characteristics of muscle in five hypotonic infants. A number of different patterns of disproportion in the sizes and numbers of type 1 and type 2 fibers were found. In three cases, type 1 fibers were smaller than type 2 fibers and type 2b or 2c fibers were largest. In one case, type 2 fibers were smaller than type 1 fibers and were reduced in number, while in a case of Prader-Willi syndrome there was a pre-ponderance of type 2 fibers that were smaller than type 1 fibers. Type 2c fibers were increased in number in all but one case. We postulate that these various patterns of fiber-type disproportion are the result of altered neural influences leading to impaired maturation of type 1 or type 2 motor units.
Author Affiliations
From the Muscular Dystrophy Group Research Laboratories, Regional Neurological Centre, Newcastle General Hospital, Newcastle upon Tyne, England.
Footnotes
Accepted for publication March 13, 1983.
Reprint requests to University Department of Medicine, Queen Elizabeth II Medical Center, Nedlands, W A 6009, Australia (Dr Mastaglia).
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