Dissociation of glucose and potassium arterial-venous differences across the forearm by acetazolamide. A possible relationship to acetazolamide's beneficial effect in hypokalemic periodic paralysis
J. E. Riggs, R. C. Griggs and R. T. Moxley 3rd
We studied the effect of acetazolamide on arterial-venous (A-V) glucose and
potassium differences across the forearm following oral glucose loading in
eight normal subjects. Administration of acetazolamide for 72 hours prior
to glucose loading resulted in increased A-V glucose differences and
decreased A-V potassium differences. Acetazolamide may, therefore, increase
glucose uptake across muscle while decreasing potassium uptake following
glucose ingestion. This glucose-potassium dissociation observed in normal
subjects may relate to acetazolamide's beneficial effect in hypokalemic
periodic paralysis.
