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Dissociation of Glucose and Potassium Arterial-Venous Differences Across the Forearm by AcetazolamideA Possible Relationship to Acetazolamide's Beneficial Effect in Hypokalemic Periodic Paralysis
Jack E. Riggs, MD;
Robert C. Griggs, MD;
Richard T. Moxley III, MD
Arch Neurol. 1984;41(1):35-38.
Abstract
• We studied the effect of acetazolamide on arterial-venous (A-V) glucose and potassium differences across the forearm following oral glucose loading in eight normal subjects. Administration of acetazolamide for 72 hours prior to glucose loading resulted in increased A-V glucose differences and decreased A-V potassium differences. Acetazolamide may, therefore, increase glucose uptake across muscle while decreasing potassium uptake following glucose ingestion. This glucose-potassium dissociation observed in normal subjects may relate to acetazolamide's beneficial effect in hypokalemic periodic paralysis.
Author Affiliations
From the Department of Neurology, West Virginia University School of Medicine, Morgantown (Dr Riggs), and the Departments of Neurology (Drs Griggs and Moxley), Medicine (Dr Griggs), and Pediatrics (Dr Moxley), University of Rochester (NY) School of Medicine and Dentistry.
Footnotes
Accepted for publication April 20, 1983.
Read in part before the 33rd annual meeting of the American Academy of Neurology, Toronto, May 1, 1981.
Reprints not available.
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