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Robert R. Muder, MD; Robert M. Lumish, MD; Guy R. Corsello, MD

Arch Neurol. 1983;40(7):445-446.

Abstract
• A 73-year-old woman with a remote history of carcinoma of the ovary had herpes zoster involving several lumbosacral dermatomes. There subsequently developed a progressive myelopathy with normal myelographie findings and CSF pleocytosis. Vidarabine (15 mg/kg/day) was given for ten days. No further progression occurred. The syndrome of progressive myelopathy following herpes zoster is rare; direct viral invasion of the cord with subsequent necrosis appears to be the pathogenic mechanism. Antiviral therapy may have halted progression, but it did not lead to recovery of function.

Author Affiliations
From the Department of Medicine, Mercy Hospital of Pittsburgh.

Footnotes
Accepted for publication Jan 3, 1983.

Reprint requests to Division of Infectious Diseases, Mercy Hospital of Pittsburgh, 1400 Locust St, Pittsburgh, PA 15219 (Dr Lumish).

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