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Perineural Spread of Cutaneous Basal and Squamous Cell CarcinomasThe Clinical Appearance of Spread Into the Trigeminal and Facial Nerves
John G. L. Morris, DM(Oxon), FRACP;
Ronald Joffe, MB BCh(Wits)
Arch Neurol. 1983;40(7):424-429.
Abstract
• Five patients were studied in whom a trigeminal or facial neuropathy resulted from perineural spread of basal or squamous cell carcinomas arising in the skin of the face. The cause of the neuropathy was not immediately apparent because there was no evidence of local skin recurrence in any of the patients after the onset of their neurologic symptoms. Pain was a prominent feature in those patients with trigeminal involvement. Radiologic investigations were helpful in only one patient. The diagnosis should be suspected when symptoms and signs are confined initially to superficial branches of the trigeminal or facial nerves and later extend to more central branches in the order in which they arise. Confirmation can be made by microscopic examination of the nerves involved.
Author Affiliations
From the Departments of Neurology, Westmead Centre (Dr Morris) and Royal North Shore Hospital (Dr Joffe), Sydney, Australia.
Footnotes
Accepted for publication Aug 6, 1982.
Read in part before the Association of Australian Neurologists, Adelaide, South Australia, May 27, 1981.
Reprint requests to Department of Neurology, Westmead Centre, PO Box 264, Sydney, NSW 2145, Australia (Dr Morris).
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