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Myeloneuropathy and Macrocytosis Associated With Nitrous Oxide Abuse
Guillermo Blanco, MD;
Henry A. Peters, MD
Arch Neurol. 1983;40(7):416-418.
Abstract
After four months of excessive nitrous oxide (N2O) exposure, a dentist had myeloneuropathy with spastic paraparesis, Lhermitte's sign, sensory shading, loss of position and vibration sense, ataxia, and impotence. Macrocytosis, hypersegmented neutrophils, and a reduced vitamin B12 level were associated with normal findings on gastric analysis and Schilling test. Complete hematologic and neurologic recovery followed N2O avoidance and vitamin therapy for six months.
Author Affiliations
From the Department of Neurology, University of Wisconsin Medical School, Madison.
Footnotes
Accepted for publication Nov 13, 1982.
Reprint requests to Department of Neurology, University of Wisconsin Medical School, 600 Highland Ave, Madison, WI 53792 (Dr Peters).
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