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Patrick F. Bray, MD; Linda C. Bloomer, PhD; V. C. Salmon; Mark H. Bagley; Paul D. Larsen, MD

Arch Neurol. 1983;40(7):406-408.

Abstract
• We studied infectious and immune mechanisms in demyelinating disease. The clinical diagnosis in this study of 313 consecutive cases of multiple sclerosis (MS) was based on the clinical conclusions of two or more neurologists and definite abnormalities in CSF lgG. Measurement of antibodies to six microbial agents was compared in 313 patients with MS and 406 controls in the same age range. Using a standardized immunofluorescent antibody (IFA) technique, we found a significantly higher prevalence of Epstein-Barr virus (EBV) infection and a higher level of serum viral capsid antigen IgG antibody titer in the MS population than in the controls. The MS population had a lower cytomegalovirus (CMV) infection rate and lower CMV complement fixing antibody production than controls. Except for the higher measles infection rate and antibody titer in patients with MS, data on the other viruses did not differ from controls.

Author Affiliations
From the Division of Pediatric Neurology, Departments of Neurology and Pediatrics (Drs Bray, Bloomer, and Larsen and Mr Bagley), and the Division of Infectious Diseases, Department of Pediatrics (Ms Salmon), University of Utah Medical Center and School of Medicine, Salt Lake City.

Footnotes
Accepted for publication Dec 16, 1982.

Reprint requests to University of Utah Medical Center, 50 N Medical Dr, Salt Lake City, UT 84132 (Dr Bray).

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