Epstein-Barr Virus Infection and Antibody Synthesis in Patients With Multiple Sclerosis

doi:10.1001/archneur.1983.04050070036006

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Vol. 40 No. 7, July 1983

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Epstein-Barr Virus Infection and Antibody Synthesis in Patients With Multiple Sclerosis

Patrick F. Bray, MD; Linda C. Bloomer, PhD; V. C. Salmon; Mark H. Bagley; Paul D. Larsen, MD

Arch Neurol. 1983;40(7):406-408.

Abstract

• We studied infectious and immune mechanisms in demyelinatingdisease. The clinical diagnosis in this study of 313 consecutivecases of multiple sclerosis (MS) was based on the clinical conclusionsof two or more neurologists and definite abnormalities in CSFlgG. Measurement of antibodies to six microbial agents was comparedin 313 patients with MS and 406 controls in the same age range.Using a standardized immunofluorescent antibody (IFA) technique,we found a significantly higher prevalence of Epstein-Barr virus(EBV) infection and a higher level of serum viral capsid antigenIgG antibody titer in the MS population than in the controls.The MS population had a lower cytomegalovirus (CMV) infectionrate and lower CMV complement fixing antibody production thancontrols. Except for the higher measles infection rate and antibodytiter in patients with MS, data on the other viruses did notdiffer from controls.

Author Affiliations

From the Division of Pediatric Neurology, Departments of Neurology and Pediatrics (Drs Bray, Bloomer, and Larsen and Mr Bagley), and the Division of Infectious Diseases, Department of Pediatrics (Ms Salmon), University of Utah Medical Center and School of Medicine, Salt Lake City.

Footnotes

Accepted for publication Dec 16, 1982.

Reprint requests to University of Utah Medical Center, 50 NMedical Dr, Salt Lake City, UT 84132 (Dr Bray).

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