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An Erythrocyte Membrane Antigen Associated With X-Linked Muscular Dystrophy
Verle E. Headings, MD, PhD;
Stephen I. O. Anyaibe, DSc;
Johnson Akindele, MS;
Magdalen Onaga, MS
Arch Neurol. 1983;40(5):300-305.
Abstract
• Goat antiserum was prepared against erythrocyte membranes obtained from a man who had X-linked muscular dystrophy. When cross-adsorbed with control membranes and tested on double immunodiffusion plates or by binding to intact erythrocytes suspended in thinlayer agar plates, this antiserum discriminated between membranes from phenotypically normal controls and dystrophic men, and between controls and obligate female dystrophy carriers. It also identified two populations among a small sample of women at risk for being dystrophy carriers.
Author Affiliations
From the Division of Medical Genetics, Department of Pediatrics and Child Health, Howard University College of Medicine, Washington, DC.
Footnotes
Accepted for publication July 4, 1982.
Reprint requests to Division of Medical Genetics, Department of Pediatrics and Child Health, Box 75, Howard University College of Medicine, Washington, DC 20059 (Dr Headings).
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