This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Results in Normal Aging and Dementia

Takahiro Amano, MD; John Stirling Meyer, MD; Takashi Okabe, MD; Terry Shaw, PhD; Karl F. Mortel, PhD

Arch Neurol. 1983;40(5):277-282.

Abstract
• Resting-state regional gray matter flow (Fg) values and cerebral vasoconstrictor responses induced by 100% oxygen inhalation were measured with the¹³³Xe inhalation method in normal healthy volunteers aged between 15 and 86 years and in patients with senile dementia of Alzheimer's type (SDAT) or multi-infarct dementia (MID). Cross-sectional analysis revealed that there were linear decreases of oxygen responses with advancing age in 84 normal volunteers between the second to ninth decades. Eleven patients with SDAT showed bilateral and symmetrical reductions of resting-state Fg values compared with 22 age-matched normal healthy volunteers. Eight patients with MID showed no significant reduction of mean Fg values compared with normal controls and patients with SDAT. Oxygen vasoconstrictive responses in SDAT were symmetrical and similar to those seen in age-matched controls. Compared with patients with SDAT, patients with MID showed reduced oxygen vasoconstrictive responses that were asymmetrical between hemispheres as well as heterogeneous within hemispheres. Testing cerebral vasoconstrictor responses by 100% oxygen inhalation is helpful for differentiating SDAT from MID.

Author Affiliations
From the Cerebrovascular Research Center, Veterans Administration Medical Center, Houston, and the Department of Neurology, Baylor College of Medicine, Houston.

Footnotes
Accepted for publication Aug 3, 1982.

Reprint requests to Cerebrovascular Research Center, Veterans Administration Medical Center, 2002 Holcombe Blvd, Houston, TX 77211 (Dr Meyer).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Cerebral oxygen vasoreactivity and cerebral tissue oxygen reactivity{dagger}
Johnston et al.
Br J Anaesth 2003;90:774-786.
ABSTRACT | FULL TEXT  

Age and Stimulus Dependency of Visually Evoked Cerebral Blood Flow Responses
Panczel et al.
Stroke 1999;30:619-623.
ABSTRACT | FULL TEXT  

Evidence for Transhemispheric Diaschisis in Unilateral Stroke
Dobkin et al.
Arch Neurol 1989;46:1333-1336.
ABSTRACT  

Hyperlipidemia Is a Risk Factor for Decreased Cerebral Perfusion and Stroke
Meyer et al.
Arch Neurol 1987;44:418-422.
ABSTRACT