This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Shinji Nakajima, MD; John Stirling Meyer, MD; Takahiro Amano, MD; Terry Shaw, PhD; Takashi Okabe, MD; Karl F. Mortel, PhD

Arch Neurol. 1983;40(5):271-276.

Abstract
• Cerebral vasoconstrictor responsiveness to 100% oxygen inhalation was measured in 149 subjects, including normal healthy volunteers and those with risk factors for cerebral arteriosclerosis (N = 87). Test results were compared among patients with hemispheric stroke and vertebrobasilar insufficiency (N = 62) with the ¹³³Xe inhalation method. Normal volunteers without risk factors (N = 49), aged 25 to 86 years, showed symmetrical vasoconstriction. Asymptomatic subjects with risk factors (N = 38) and those with vertebrobasilar insufficiency (N = 25) had decreased hemispheric gray matter flow (Fg) values during rest, but vasoconstrictor responsiveness to 100% oxygen inhalation was not significantly reduced. In patients with acute hemispheric infarction, regional vasoconstrictor responsiveness to 100% oxygen inhalation was lost and/or paradoxically reversed; in patients with chronic hemispheric infarction, it was decreased. Testing vasomotor responses during hyperoxia is safe, clinically helpful, and demonstrates impaired vasomotor reactivity in infarcted regions.

Author Affiliations
From the Cerebrovascular Research Center, Veterans Administration Medical Center, Houston, and the Department of Neurology, Baylor College of Medicine, Houston.

Footnotes
Accepted for publication Aug 3, 1982.

Reprint requests to Cerebrovascular Research Center, Veterans Administration Medical Center, 2002 Holcombe Blvd, Houston, TX 77211 (Dr Meyer).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia
Shin et al.
Brain 2007;130:1631-1642.
ABSTRACT | FULL TEXT  

A Pilot Study of Normobaric Oxygen Therapy in Acute Ischemic Stroke
Singhal et al.
Stroke 2005;36:797-802.
ABSTRACT | FULL TEXT  

Cerebral oxygen vasoreactivity and cerebral tissue oxygen reactivity{dagger}
Johnston et al.
Br J Anaesth 2003;90:774-786.
ABSTRACT | FULL TEXT  

Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke
Singhal et al.
Neurology 2002;58:945-952.
ABSTRACT | FULL TEXT  

Cigarette Smoking Decreases Cerebral Blood Flow Suggesting Increased Risk for Stroke
Rogers et al.
JAMA 1983;250:2796-2800.
ABSTRACT