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Coupling Between Regional Blood Flow and Oxygen Utilization in the Normal Human BrainA Study With Positron Tomography and Oxygen 15
Philippe Lebrun-Grandié, MD;
Jean-Claude Baron, MD;
Françoise Soussaline, PhD;
Christian Loch'h;
Jacqueline Sastre;
Marie-Germaine Bousser, MD
Arch Neurol. 1983;40(4):230-236.
Abstract
• Using the oxygen 15 continuousinhalation technique and positron emission tomography (PET), the regional cerebral blood flow (rCBF), oxygen extraction fraction (rOEF) and oxygen utilization (rCMR02) were measured in 19 control subjects. The rCBF and rCMR02 values, computed for small regions of interest (ROI), were within accepted normal ranges. Larger, more convenient ROI provided values for gray and white matter regions that were, respectively, lower and higher than those found using small ROI. The rOEF values were not affected by the ROI size, but seemed to slightly overestimate real OEF. These findings may be explained by (1) the partial volume effect, and (2) some limitations of the1S0 steady state model. The150-PET technique therefore provides representative but clinically useful physiological indexes. In addition, our study demonstrated the normal coupling between local oxygen supply and demand.
Author Affiliations
From the Commissariat à l'Energie Atomique, Département de Biologie, Service Hospitalier Frédéric-Joliot, Orsay, Prance (Drs Lebrun-Grandié, Baron, and Soussaline, Mr Loch'h, and Ms Sastre); and the Clinique des Maladies du Système Nerveux (Prof P. Castaigne), La Salpétrière, Paris (Dr Bousser).
Footnotes
Accepted for publication May 29, 1982.
Read in part before the Tenth International Symposium on Cerebral Blood Flow and Metabolism, St Louis, June 20, 1981.
Reprint requests to Service Hospitalier Frédéric-Joliot, 91406 Orsay, France (Dr Baron).
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