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Linda E. Nee, MSW; Ronald J. Polinsky, MD; Roswell Eldridge, MD; Herbert Weingartner, PhD; Sheila Smallberg; Michael Ebert, MD

Arch Neurol. 1983;40(4):203-208.

Abstract
• A Canadian family comprising 51 members affected with Alzheimer's disease was evaluated clinically, histologically, and genetically. Ancestors were traced through eight generations, and 51 members were examined at the National Institute of Mental Health, Bethesda, Md. The pedigree is consistent with autosomal dominant inheritance. The effect of interrelatedness among some parents of affected individuals is unknown. In contrast to other studies, there was not an increased incidence of Down's syndrome, hematologic malignancy, or preponderance of affected females.

Author Affiliations
From the Laboratories of Clinical Science (Ms Nee and Drs Polinsky and Ebert) and Psychology and Psychopathology (Dr Weingartner and Ms Smallberg), National Institute of Mental Health, and Clinical Neurogenetic Studies, National Institute of Neurological and Communicative Diseases and Stroke (Dr Eldridge), Bethesda, Md.

Footnotes
Accepted for publication March 15, 1982.

Reprint requests to Room 3S231, Clinical Center, National Institute of Mental Health, Bethesda, MD 20205 (Ms Nee).

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