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Creatine Kinase BB Isoenzyme in CSF in Neurologic DiseasesMeasurement by Radioimmunoassay
Frederick E. Pfeiffer, MD;
Henry A. Homburger, MD;
Takehiko Yanagihara, MD
Arch Neurol. 1983;40(3):169-172.
Abstract
• The concentration of creatine kinase BB isoenzyme (CK BB) was measured by radioimmunoassay in CSF from 306 patients with various neurologic disorders. Levels above 2.0 ng/ml were not found in patients without neurologic disease. Whereas mean CSF CK BB level was less than 2.0 ng/mL in groups of patients with systemic malignant neoplasms, latent syphilis, peripheral neuropathy, disk disease, polyradiculopathy, myelopathy, multiple sclerosis, neurodegenerative disease, encephalopathy, and hydrocephalus, it was elevated in groups of patients with convulsive disorder, CNS neoplasm, cerebrovascular disease, vasculitis, and meningoencephalitis.
Author Affiliations
From the Departments of Neurology (Drs Pfeiffer and Yanagihara) and Laboratory Medicine (Dr Homburger), Mayo Clinic and Mayo Foundation, Rochester, Minn.
Footnotes
Accepted for publication April 15, 1982.
Reprint requests to Department of Neurology, Mayo Clinic, Rochester, MN 55905 (Dr Yanagihara).
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