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Its Effect on Seizure Frequency

Christopher F. Terrence, MD; Gerhard H. Fromm, MD; Matei S. Roussan, MD

Arch Neurol. 1983;40(1):28-29.

Abstract
• Baclofen has been reported to be epileptogenic in man, but many animal studies have demonstrated an anticonvulsant effect. In 12 patients with a history of epilepsy, baclofen was given in the conventional dosage range. In the six patients with anticonvulsant-controlled seizures, none had a seizure during baclofen therapy. In the six patients with uncontrolled epilepsy, two patients had one more seizure per month while receiving baclofen, and a third went from four seizures per month to one per month. Baclofen does not appear to have a deleterious effect in patients with epilepsy.

Author Affiliations
From the Neurology Service, Veterans Administration Medical Center, Pittsburgh (Dr Terrence); the Department of Neurology, University of Pittsburgh School of Medicine (Dr Fromm); and the Department of Rehabilitation Medicine, Albert Einstein College of Medicine, Bronx, NY (Dr Roussan).

Footnotes
Accepted for publication June 1, 1982.

Reprint requests to Neurology Service (127), Veterans Administration Medical Center, Pittsburgh, PA 15240 (Dr Terrence).

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