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Posttraumatic Premature Alzheimer's DiseaseNeuropathologic Findings and Pathogenetic Considerations
Raul Rudelli, MD;
John O. Strom, MD;
Paul T. Welch, MD;
Mary W. Ambler, MD
Arch Neurol. 1982;39(9):570-575.
Abstract
Dementia following head trauma is generally attributed to contusional injury or its complications. Dementia pugilistica and rare cases of classic Alzheimer's disease (AD) following head injury suggest that trauma may also play a provocative role in neurofibrillary change. The ages and clinical descriptions, however, allow other interpretations. A 38-year-old man died 16 years after substantial recovery from a single episode of severe head trauma. Pathologic study indicated that the clinical deterioration was due to classic AD. Ultrastructural evaluation demonstrated both paired helical and straight filaments in cortical neurons.
Author Affiliations
From the Departments of Neurology (Drs Strom and Ambler), Neurosurgery (Dr Welch), and Pathology (Drs Rudelli and Ambler), Rhode Island Hospital and Brown University, Providence. Dr Rudelli is now with the Institute for Basic Research in Mental Retardation, New York.
Footnotes
Accepted for publication Aug 8, 1981.
Read in part before the 56th annual meeting of the American Association of Neuropathology, New Orleans, June 14, 1980.
Reprint requests to Rhode Island Hospital, 593 Eddy St, Providence, RI 02902 (Dr Ambler).
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